Cyclovirobuxin D

Research use only, not for human use.

Extracted from Buxus microphylla.

Extracted from Buxus microphylla;Suitability:Chloroform,methanol and ethanol;Store the product in sealed,cool and dry condition.

Cyclovirobuxine D (0-240 μM ;24-72 hours) shows a concentration- and time-dependent reduced cell viability after CVB-D treatment, only 10% MGC-803 cells and 20% MKN28 cells are alive at 72 h after treatment with 240 μM.Cyclovirobuxine D (0-120 μM; 48 hours) arrests the cell cycle of gastric cancer cells at S phase in a concentration-dependent manner.Cyclovirobuxine D (0-120 μM; 48 hours) leads to apoptosis in gastric cancer cells in a concentration-dependent manner, especially early stage apoptosis.Cyclovirobuxine D (0-120 μM; 48 hours) causes apoptosis via up-regulation of the apoptosis- related proteins, cleaved Caspase-3 and ratio of Bax/Bcl-2, in gastric cancer cells. Cell Viability Assay Cell Line:MGC-803 and MKN28 cells Concentration:0, 30, 60, 120 and 240 μM Incubation Time:24, 48, 72 hours Result:Reduced Cell Viability and Colony Formation Ability of Gastric Cancer Cells Cell Cycle Analysis Cell Line:MGC-803 and MKN28 cells Concentration:0, 30, 60, and 120 μM Incubation Time:48 hours Result:Arrested cell cycle progressions of MGC-803 and MKN28 cells.Apoptosis Analysis Cell Line:MGC-803 and MKN28 cells Concentration:0, 30, 60, and 120 μM Incubation Time:48 hours Result:Induced apoptosis of MGC-803 and MKN28 cells.Western Blot Analysis Cell Line:MGC-803 and MKN28 cells Concentration:0, 30, 60, and 120 μM Incubation Time:48 hoursResult:Up-regulated cleaved Caspase-3 and Bax and decreased the expression of Bcl-2 expression.

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CVB-D | NSC 91722

Others

Other Targets

Others

Other Indications

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860-79-7

402.66

C26H46N2O

>98% (HPLC)

Ethanol: 20 mg/mL (49.66 mM)

C[C@H](NC)[C@H]1[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@@]4([H])C(C)(C)[C@@H](NC)CC[C@]4(C5)[C@@]35CC[C@]12C

9,19-Cyclo-5-alpha,9-beta-pregnan-16-alpha-ol, 4,4,14-trimethyl-3-beta,20-alpha-bis(methylamino)-

(-20℃)

With Ice Pack

≥ 2 years